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Volunteer to take part in a study!

RESEARCH STUDIES CURRENTLY RECRUITING:

 

Carotid Body in Young Onset Hypertension

We think that a small organ in the neck called the carotid body may be overactive in high blood pressure. We wish to understand this better and are looking to recruit young adults (aged 18-39) with and without high blood pressure. The study involves 2 visits consisting of an exercise test called a VO2 peak and some breathing tests at rest and during exercise.

Please contact Thomas.hinton@bristol.ac.uk or 01173421513 if interested.

 

Minocycline in Chronic Heart Failure (MINOH-HF) - Pilot Study

We are looking for patients with heart failure to take part in a small study looking at the potential role of a drug called Minocycline. This is normally used as a treatment for acne but we think this may have some properties that could be of benefit in heart failure but this has not been previously tested. The study involves 3 visits over a 3 month period whilst taking Minocycline. During the visits there will be some assessments of nerve activity, breathing and an exercise test.

Please contact Thomas.hinton@bristol.ac.uk  or  01173421513 if interested.

 

Blunting the Blood Pressure Response to Exercise Using Beetroot Juice


Beetroot Juice Exercise Blood Pressure. We are recruiting individuals with controlled high blood pressure between ages 50-75. The study involves 4 visits over a one month period whilst taking beetroot juice. The visits consist of exercise tests called a VO2 peak on a bike and some handgrip tests. 

Please contact Benjamin Chant at bc15666@bristol.ac.uk or 01173421513 if interested.

 

Chemoreceptor reflex antagonism during LBNP

This study is looking for healthy volunteers aged 18-75 years, with normal blood pressure, to take part.

About the study:

This study is investigating the role of the carotid bodies (small organs in the neck) in the control of blood pressure. To do this we apply negative pressure (suction) to the lower body in order to challenge blood pressure. We then use low doses of dopamine to decrease the activity of the carotid bodies. This allows us to measure whether the body's response to a blood pressure challenge is altered by the carotid bodies becoming less active. 

The study involves:

  • A 45-minute screening visit and a two-hour study visit, both at CRICBristol;
  • Wearing an at-home blood pressure monitor to measure blood pressure over 24 hours between the visits;
  • Lying in a lower body negative pressure chamber which applies suction (via a vacuum device connected to the chamber) from the waist down;
  • Receiving a low dose of dopamine through a cannula (tube) in a vein in the arm or hand;
  • Brief periods breathing extra nitrogen than normal in order to reduce your oxygen levels (hypoxia). The nitrogen will be given through a facemask.

For more information and to sign up for the study, please email cardionomics-cb-study@bristol.ac.uk, or telephone 01173421513

 

  

Autoregulation of Brain Blood Flow in Hypertension

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1.    What is this study?

Our research team (Bristol Heart Institute CardioNomics Group) is carrying out a study investigating the dynamics of brain blood flow in individuals with high blood pressure; also known ashypertension.

2.    Why is this study important?

High blood pressure is the biggest risk factor which leads to a stroke and/or a heart attack. It is also a major risk factor in the development of diseases such as heart and kidney failure.  The major problem with high blood pressure is that many people do not know they have hypertension as there are no common symptoms. Therefore many people do not know they have high blood pressure until it is too late.

It has been suggested that high blood pressure might alter the blood flow to the brain. This could mean that we need to make adjustments to current treatments of hypertension. This study therefore focuses on the dynamics of blood flow to the brain (measured during MRI) and how the blood flow is adjusted when blood pressure is changed.

3.    Who can take part?

We are looking to recruit people with high or normal blood pressure that also meet the criteria below:

  • Men.
  • Women who are not pregnant.
  • Ages 18-75 years.
  • Individuals with no known major illnesses.

4.    What will taking part involve?

The study involves 2 visits:

A)     Screening visit (completed at University Hospitals Bristol). This includes:

  • ECG of your heart.
  • Urine dipstick test.
  • Blood pressure measurement.
  • A 24 hour blood pressure monitor to measure at home blood pressure

B)     MRI visit (completed at the Bristol Heart Institute, Bristol). This involves:

  • An MRI scan of your brain to measure brain blood flow.
  • Negative pressure applied to your lower body to change blood pressure

Click here for more information about MRI scans.

PLEASE NOTE: YOU WILL BE COMPENSATED FOR YOUR TRAVEL

5.    What are the benefits of taking part?

Taking part in this research study is completely voluntary. However, if you decide to participate it will help us understand A) how we can prevent high blood pressure and B) what new therapies we can develop to help control blood pressure in people with hypertension.

You will receive information about your blood pressure which may be of some benefit to you.

6.    Who is funding the study?

This study is funded by the Bristol Heart Institute Biomedical Research Unit, the British Heart Foundation and the Wellcome Trust with support from University Hospitals Bristol NHS Foundation Trust.

7.    Who can I contact for more information?

A)     Miss Sandra Neumann (PhD Student)

Email: Sandra.Neumann@Bristol.ac.uk

Tel: 0117 342 1503

B)     Dr. Emma C. Hart (Chief Investigator)

Email: emma.hart@bristol.ac.uk

Tel: 0117 331 1472

Carotid body and exercise study

 Katrina Hope Exercise Study

Is peripheral chemosensitivity different in exercise between hypertensive versus normotensive humans?

The University of Bristol and BHI CardioNomics Group are seeking volunteers to participate in a research study. We think that the carotid body (a tiny gland in the neck) may be overactive in people with high blood pressure.  This study will compare the way the carotid body works in people with high blood pressure compared to healthy volunteers during exercise.

We are looking to recruit both people with high and normal blood pressure.

You may be eligible to participate if:

  • You are aged 18 - 75 years
  • You do not have COPD or emphysema
  • You do not drink more than 28 units of alcohol/week
  • You are not involved in any other interventional research study 

The visits are on 2 different days. One visit is <1 hr, the other 4-6 hrs. This includes:

  • Blood pressure check, ECG (heart tracing) and blood tests
  • Measuring breathing responses to different gases and a drug given into a vein
  • Cycling fitness test on an exercise bike 

You will be compensated £45 for your time and travel expenses. 

For more information, please contact Dr. Katrina Hope on:
0117 342 1513 or katrina.hope@bristol.ac.uk