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Volunteer to take part in a study!

***Coming soon***  in April 2016: Exercise pressor reflex in humans with hypertension

We will be looking for people aged 18-75 with high blood pressure, not yet fully controlled by medication. Check back here soon or email Ben Chant on bc15666@bristol.ac.uk for more information.

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RESEARCH STUDIES CURRENTLY RECRUITING:

Autoregulation of Brain Blood Flow in Hypertension

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1.    What is this study?

Our research team (Bristol Heart Institute CardioNomics Group) is carrying out a study investigating the dynamics of brain blood flow in individuals with high blood pressure; also known ashypertension.

2.    Why is this study important?

High blood pressure is the biggest risk factor which leads to a stroke and/or a heart attack. It is also a major risk factor in the development of diseases such as heart and kidney failure.  The major problem with high blood pressure is that many people do not know they have hypertension as there are no common symptoms. Therefore many people do not know they have high blood pressure until it is too late.

It has been suggested that high blood pressure might alter the blood flow to the brain. This could mean that we need to make adjustments to current treatments of hypertension. This study therefore focuses on the dynamics of blood flow to the brain (measured during MRI) and how the blood flow is adjusted when blood pressure is changed.

3.    Who can take part?

We are looking to recruit people with high or normal blood pressure that also meet the criteria below:

  • Men.
  • Women who are not pregnant.
  • Ages 18-75 years.
  • Individuals with no known major illnesses.

4.    What will taking part involve?

The study involves 2 visits:

A)     Screening visit (completed at University Hospitals Bristol). This includes:

  • ECG of your heart.
  • Urine dipstick test.
  • Blood pressure measurement.
  • A 24 hour blood pressure monitor to measure at home blood pressure

B)     MRI visit (completed at the Bristol Heart Institute, Bristol). This involves:

  • An MRI scan of your brain to measure brain blood flow.
  • Negative pressure applied to your lower body to change blood pressure

Click here for more information about MRI scans.

PLEASE NOTE: YOU WILL BE COMPENSATED FOR YOUR TRAVEL

5.    What are the benefits of taking part?

Taking part in this research study is completely voluntary. However, if you decide to participate it will help us understand A) how we can prevent high blood pressure and B) what new therapies we can develop to help control blood pressure in people with hypertension.

You will receive information about your blood pressure which may be of some benefit to you.

6.    Who is funding the study?

This study is funded by the Bristol Heart Institute Biomedical Research Unit, the British Heart Foundation and the Wellcome Trust with support from University Hospitals Bristol NHS Foundation Trust.

7.    Who can I contact for more information?

A)     Miss Sandra Neumann (PhD Student)

Email: Sandra.Neumann@Bristol.ac.uk

Tel: 0117 342 1503

B)     Dr. Emma C. Hart (Chief Investigator)

Email: emma.hart@bristol.ac.uk

Tel: 0117 331 1472

Carotid body and exercise study

 Katrina Hope Exercise Study

Is peripheral chemosensitivity different in exercise between hypertensive versus normotensive humans?

The University of Bristol and BHI CardioNomics Group are seeking volunteers to participate in a research study. We think that the carotid body (a tiny gland in the neck) may be overactive in people with high blood pressure.  This study will compare the way the carotid body works in people with high blood pressure compared to healthy volunteers during exercise.

We are looking to recruit both people with high and normal blood pressure.

You may be eligible to participate if:

  • You are aged 18 - 75 years
  • You do not have COPD or emphysema
  • You do not drink more than 28 units of alcohol/week
  • You are not involved in any other interventional research study 

The visits are on 2 different days. One visit is <1 hr, the other 4-6 hrs. This includes:

  • Blood pressure check, ECG (heart tracing) and blood tests
  • Measuring breathing responses to different gases and a drug given into a vein
  • Cycling fitness test on an exercise bike 

You will be compensated £45 for your time and travel expenses. 

For more information, please contact Dr. Katrina Hope on:
0117 342 1513 or katrina.hope@bristol.ac.uk

  

Brain blood flow and high blood pressure study

What is this study?

Our research team (Bristol Heart Institute CardioNomics Group) is carrying out a study investigating the role that the brain plays in the development of high blood pressure; also known as hypertension.

Why is this study important?

High blood pressure is the biggest risk factor which leads to a stroke and/or a heart attack. It is also a major risk factor in the development of diseases such as heart and kidney failure.  The main problem with high blood pressure is that many people do not know they have hypertension as there are no common symptoms. Therefore many people do not know they have high blood pressure until it is too late.

Unfortunately, the processes that lead to high blood pressure are not well understood.  This can make it difficult to treat in some individuals. Our group think that the brain and blood flow to it plays a major role in the development of high blood pressure. This study focuses on blood flow to the brain (measured using Magnetic Resonance Imaging) and how the brain controls blood pressure (using measures of nerve activity directed to the blood vessels).

Who can take part?

We are looking to recruit people with high or normal blood pressure that also meet the criteria below:

  • Men.
  • Women who are not pregnant.
  • Ages 18-75 years.
  • Individuals with no known major illnesses.
  • Not involved in any other research study

What will taking part involve?

The study involves 2 visits:

A)     Screening visit (completed at University Hospitals Bristol). This includes:

  • ECG (tracing of your heart's electrical activity).
  • Urine dipstick test.
  • Blood pressure measurement.
  • Nerve testing measurements.
  • Blood taking (equivalent to 4 table spoons).
  • A 24 hour blood pressure monitor to measure at home blood pressure

B)     MRI visit (completed at Cardiff University Brain Imaging Centre). This involves:

 PLEASE NOTE: YOU WILL BE COMPENSATED FOR YOUR TRAVEL

What are the benefits of taking part?

Taking part in this research study is completely voluntary. By participating you would help us understand how we might prevent high blood pressure and develop new treatments to help control blood pressure in people with hypertension.

You will receive a health and blood pressure screen which may be of some benefit to you.

Who is funding the study?

This study is funded by the British Heart Foundation.

 Who can I contact for more information?

A) Dr. Emma C. Hart (Chief Investigator)

Email: emma.hart@uhbristol.nhs.uk

Tel: 0117 331 1472

B) Jenny Wilcox (Research Nurse)

Email: jennifer.wilcox@uhbristol.nhs.uk

Tel: 0117 342 1513

What research institutes does the study involve?

A)     University of Bristol

B)     University Hospitals Bristol

C)     Cardiff University