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Research findings and publications

Carotid body and high blood pressure

Targeting autonomic imbalance in pathophysiology: is the carotid body the new nirvana?  Paton JF. J Physiol. 2017;595(1):29-30.

Purinergic receptors in the carotid body as a new drug target for controlling hypertension. Pijacka W, Moraes DJA, Ratcliffe LEK, Nightingale AK, Hart EC, da Silva MP, et al. Nat Med. 2016;22(10):1151-9.

Unilateral Carotid Body Resection in Resistant Hypertension: A Safety and Feasibility Trial. Narkiewicz K, Ratcliffe LE, Hart EC, Briant LJ, Chrostowska M, Wolf J, et al. JACC Basic to translational science. 2016;1(5):313-24. August

Evaluating the carotid bodies and renal nerves as therapeutic targets for hypertension. McBryde FD, Hart EC, Ramchandra R, Paton JF. Autonomic neuroscience : basic & clinical. 2016.

CrossTalk opposing view: Which technique for controlling resistant hypertension? Carotid chemoreceptor denervation/modulation.   Ratcliffe LEK, Pijacka W, McBryde FD, Abdala AP, Moraes DJ, Sobotka PA, Hart EC, Narkiewicz K, Nightingale AK, Paton JFR.  J Physiol.2014;592(18): 3941-4. 

The carotid body as a putative therapeutic target for the treatment of neurogenic hypertension. McBryde FD, Abdala AP, Hendy EB, Pijacka W, Marvar P, Moraes DJA, Sobotka PA, Paton JFR.  Nat Commununications(online) 2013; 4: 2395.  doi: 10.1038/ncomms3395.  http://www.nature.com/ncomms/2013/130903/ncomms3395/full/ncomms3395.html

Response to role of the carotid body in obesity-related sympathoactivation.  Paton JF, Sobotka PA, Fudim M, Engelman ZJ, Hart EC, McBryde FD, Abdala AP, Marina N, Gourine AV, Lobo M, Patel N, Burchell A, Ratcliffe L, Nightingale A. Hypertension 2013; 61: e58.

Revelations about carotid body function through its pathological role in resistant hypertension.  Paton JF, Ratcliffe L, Hering D, Wolf J, Sobotka PA, Narkiewicz K.  Curr Hypertens Rep2013 [Epub ahead of print] http://link.springer.com/article/10.1007%2Fs11906-013-0366-z/fulltext.html

The carotid body as a therapeutic target for the treatment of sympathetically mediated diseases.  Paton JF, Sobotka PA, Fudim M, Engleman ZJ, Hart EC, McBryde FD, Abdala AP, Marina N, Gourine AV, Lobo M, Patel N, Burchell A, Ratcliffe L, Nightingale A.  Hypertension2013; 61(1): 5-13.  http://hyper.ahajournals.org/content/61/1/5.long 

 

Renal denervation

Renal artery sympathetic denervation: observations from the UK experience. Sharp AS, Davies JE, Lobo MD, Bent CL, Mark PB, Burchell AE, et al. Clinical research in cardiology : official journal of the German Cardiac Society.  2016;105(6):544-52.

Controversies Surrounding Renal Denervation: Lessons Learned From Real-World Experience in Two United Kingdom Centers. Burchell AE, Chan K, Ratcliffe LE, Hart EC, Saxena M, Collier DJ, et al. J Clin Hypertens (Greenwich). 2016;18(6):585-92.

High variable response to renal denervation for resistant hypertension - real world experience from 2 UK centres.  Burchell A, Chan K, Ratcliffe L, Hart E, Saxena M, Collier D, Jain A, Mathur A, Knight C, Caulfield M, Paton J, Nightingale A, Baumbach A, Lobo M.Journal of Human Hypertension2014;28(1): S29. 

Translational examination of changes in baroreflex function after renal denervation in hypertensive rats and humans.  Hart EC, McBryde FD, Burchell AE, Ratcliffe LE, Stewart LQ, Baumbach A, Nightingale A, Paton JF.  Hypertension2013 [Epub ahead of print] http://hyper.ahajournals.org/content/early/2013/07/01/HYPERTENSIONAHA.113.01261.reprint

Renal denervation improves autonomic responses to falls in blood pressure.  Ratcliffe LEK, Hart EC, Burchell AE, Baumbach A, Paton JFR, Nightingale AK.  Heart2013; 99: suppl 2 A77. http://heart.bmj.com/content/99/suppl_2/A77.2.abstract

Renal denervation for resistant hypertension: safety and response rate at 6 months in a UK population. Burchell AE, Ratcliffe LEK, Hart EC, Stewart LQ, Baumbach A, Paton JFR, Nightingale AK.  Heart2013; 99: suppl 2 A78.  http://heart.bmj.com/content/99/suppl_2/A78.1

Normal range sympathetic tone in resistant hypertension associated with blood pressure increase following renal denervation in a pre-menopausal woman.  Baumbach A, Burchell AE, Hart EC, Paton JFR, Nightingale AK. International Journal of Cardiology2013.  doi:10.1016/j.ijcard.2013.04.028

 

Deep brain stimulation

Deep brain stimulation for the treatment of resistant hypertension.  O'Callaghan EL, McBryde FD, Burchell AE, Ratcliffe LE, Nicolae L, Gillbe I, Carr D, Hart EC, Nightingale AK, Patel NK, Paton JFR. Curr Hypertens Rep. 2014 Nov;16(11):493. 

Deep brain stimulation relieves refractory hypertension.  Patel, N.K., Javed, S., Khan, S. Papouchado, M., Malizia, A., Pickering, AE &Paton J.F.R. Neurology2011;76: 405-407.

 

Inflammation and hypertension

Excessive leukotriene B4 in nucleus tractus solitarii is pro-hypertensive in spontaneously hypertensive rats. Waki, H., Hendy, E., Murphy, D., Kasparov, S. & Paton, J.F.R.Hypertension2013;61: 194-201.

Upregulation of junctional adhesion molecule-1 is associated with experimental and clinical hypertension. Xu, H., Oliveira-Sales, E.B., Toward, M., Graham, D., Dominiczak, A.F., Ascione, R., Waki, H., Kasparov*, S. & Paton, J.F.R.*(2012).Cardiovascular Research2012;96:552-560.

The sympathetic nervous system and blood pressure in humans: implications for hypertension. Fisher, J.P. & Paton J.F.R. Journal of Human Hypertension2012;26: 463-475.

Autonomic-Immune-Vascular Interaction: An Emerging Concept for Neurogenic Hypertension. Zubcevic.J., Waki, H. Raizada, M.K. & Paton, J.F.R. Hypertension2011;57:1026-1033.

Contributions of vascular inflammation in the brainstem for neurogenic hypertension. Waki, H., Gouraud, S.S., Maeda, M., Raizada, M.K. & Paton, J.F.R.  Respiration Physiology & Neurobiology2011; 178: 422-428.

 

General hypertension

Comprehensive First-Line Magnetic Resonance Imaging in Hypertension: Experience From a Single-Center Tertiary Referral Clinic. Burchell AE, Rodrigues JC, Charalambos M, Ratcliffe LE, Hart EC, Paton JF, et al. J Clin Hypertens (Greenwich). 2017;19(1):13-22.

Human hypertension, sympathetic activity and the selfish brain.  Hart EC.  Exp Physiol. 2016;101(12):1451-62. 

Prevalence and predictors of asymmetric hypertensive heart disease: insights from cardiac and aortic function with cardiovascular magnetic resonance. Rodrigues JC, Amadu AM, Dastidar AG, Hassan N, Lyen SM, Lawton CB, et al. European heart journal cardiovascular Imaging. 2016;17(12):1405-13.

Is High Blood Pressure Self-Protection for the Brain?  Warnert EA, Rodrigues JC, Burchell AE, Neumann S, Ratcliffe LE, Manghat NE, et al.Circulation Research. 2016.

The Relationship Between Left Ventricular Wall Thickness, Myocardial Shortening, and Ejection Fraction in Hypertensive Heart Disease: Insights From Cardiac Magnetic Resonance Imaging. Rodrigues JC, Rohan S, Dastidar AG, Trickey A, Szantho G, Ratcliffe LE, et al. J Clin Hypertens (Greenwich). 2016;18(11):1119-27.

Comprehensive characterisation of hypertensive heart disease left ventricular phenotypes. Rodrigues JC, Amadu AM, Dastidar AG, Szantho GV, Lyen SM, Godsave C, et al. Heart. 2016;102(20):1671-9. 

Quantifying sympathetic neuro-haemodynamic transduction at rest in humans: insights into sex, ageing and blood pressure control.  Briant LJ, Burchell AE, Ratcliffe LE, Charkoudian N, Nightingale AK, Paton JF, et al. J Physiol. 2016;594(17):4753-68.

Electrocardiographic detection of hypertensive left atrial enlargement in the presence of obesity: re-calibration against cardiac magnetic resonance.  Rodrigues JC, Erdei T, Dastidar AG, McIntyre B, Burchell AE, Ratcliffe LE, et al. J Hum Hypertens. 2016.

Hypertensive heart disease versus hypertrophic cardiomyopathy: multi-parametric cardiovascular magnetic resonance discriminators when end-diastolic wall thickness >/= 15 mm. Rodrigues JC, Rohan S, Ghosh Dastidar A, Harries I, Lawton CB, Ratcliffe LE, et al. European radiology. 2016.

ECG strain pattern in hypertension is associated with myocardial cellular expansion and diffuse interstitial fibrosis: a multi-parametric cardiac magnetic resonance study. Rodrigues JC, Amadu AM, Ghosh Dastidar A, McIntyre B, Szantho GV, Lyen S, et al. European heart journal cardiovascular Imaging. 2016.

Precursors of Hypertensive Heart Phenotype Develop in Healthy Adults: An Alternative Explanation. Rodrigues JC, Dastidar AG, Paton JF, MacIver DH. JACC Cardiovascular imaging. 2016;9(6):762-3.

The effect of obesity on electrocardiographic detection of hypertensive left ventricular hypertrophy: recalibration against cardiac magnetic resonance. Rodrigues JC, McIntyre B, Dastidar AG, Lyen SM, Ratcliffe LE, Burchell AE, et al.J Hum Hypertens. 2016;30(3):197-203. 

Sympathetic regulation of blood pressure in normotension and hypertension: when sex matters. Briant LJ, Charkoudian N, Hart EC. Exp Physiol. 2016;101(2):219-29.

Cerebrovascular Abnormalities Supporting the Selfish Brain Hypothesis of Human Hypertension. FASEB J April 2015; 29: 646.6.  Hart E, Rodrigues J, Ratcliffe L, Burchell A, Manghat N, Wise R, Nightingale A, Paton J.

Phenotyping patterns of left ventricular remodelling and hypertrophy in systemic hypertension by cardiac magnetic resonance (CMR).   Journal of Cardiovascular Magnetic Resonance 2015, 17(Suppl 1):P323.  Jonathan C Rodrigues, Stephen Lyen, Amardeep Ghosh Dastidar, Neelam Hassan, Amy E Burchell, Laura E Ratcliffe, Emma C Hart, Chiara Bucciarelli-Ducci, Mark Hamilton, Julian F Paton, Angus K Nightingale, Nathan E Manghat. 

Improving the poor diagnostic accuracy of the ECG at detecting prognostically significant left ventricular hypertrophy in hypertensive patients.  Journal of Cardiovascular Magnetic Resonance 2015, 17(Suppl 1):P324.  Jonathan C Rodrigues, Bethanie McIntyre, Amardeep Ghosh Dastidar, Amy E Burchell, Laura E Ratcliffe, Emma C Hart, Julian F Paton, Chiara Bucciarelli-Ducci, Mark Hamilton, Angus K Nightingale, Nathan E Manghat.

Insights from cardiovascular magnetic resonance imaging supporting the selfish brain hypothesis of arterial hypertension.  Journal of Cardiovascular Magnetic Resonance 2015, 17(Suppl 1):P405.  Jonathan C Rodrigues, Emma C Hart, Neelam Hassan, Mandy Williams, Amy E Burchell, Laura E Ratcliffe, Angus K Nightingale, Julian F Paton, Nathan E Manghat. 

Should we screen for intracranial aneurysms (IAs) in systemic hypertension at the time of cardiac magnetic resonance (CMR)?  Journal of Cardiovascular Magnetic Resonance 2015, 17(Suppl 1):P411.  Jonathan C Rodrigues, Neelam Hassan, Mandy Williams, Amy E Burchell, Laura E Ratcliffe, Mark Hamilton, Emma C Hart, Angus K Nightingale, Julian F Paton, Nathan E Manghat. 

Hypertension and the brain: which treatments could improve cerebral blood flow.  Coope T, Nightingale A,Ratcliffe L, Burchell A, Wise R, Paton J, Hart E. Journal of Human Hypertension2014;28(1): S23. 

Arteriovenous anastomosis: is this the way to control hypertension?   Burchell, AE, Lobo, MD, Sulke, N, Sobotka, PA & Paton, J.F.R.Hypertension2014;64: 6-12.

Restoring autonomic balance: future therapeutic targets.   Sobotka PA, Osborn JW, Paton JF.   EuroIntervention 2013; 22 (9) Suppl R: R140-8. doi: 10.4244/EIJV9SRA24.

Utility of MRI as the primary imaging tool in hypertension.  Amy E Burchell, Laura E Ratcliffe, Andreas Baumbach, Angus K Nightingale, Nathan Manghat Journal of Cardiovascular Magnetic Resonance2014,16(Suppl 1):P248

MRI is a safe and effective imaging strategy in the investigation of resistant hypertension.  Burchell AE, Ratcliffe LEK, Hart EC, Stewart LQ, Lee A, Paton JFR, Manghat NE, Nightingale AK. Journal of Human Hypertension2013;27: 636.

End organ damage in new referrals to a hypertension clinic. Ratcliffe LEK, Burchell AE, Manghat NE, Paton JFR, Nightingale AK. Journal of Human Hypertension2013;27: 648.

Neurogenic hypertension and elevated vertebrobasilar arterial resistance: is there a causative link?  Cates MJ, Dickinson CJ, Hart EC, Paton JFR. Curr Hypertension Reports 2012;14: 261-269.

Harvey Cushing and the regulation of blood pressure in giraffe, rats and man: introducing Cushing's mechanism. Paton J.F.R., Dickinson, C.J., Mitchell, G. Experimental Physiology2009;94: 11-17.

 

 Amy BCS 2013       Laura BCS 2013        

Posters at the British Cardiovascular Society Meeting 2013